University of Glasgow

Academic Institute

Bhautesh Jani - Chief Investigator - University of GlasgowBhautesh Jani - Corresponding Applicant - University of GlasgowBarbara Nicholl - Collaborator - University of GlasgowFrances Mair - Collaborator - University of GlasgowJill Pell - Collaborator - University of GlasgowMohammad H Derakhshan - Collaborator - University of GlasgowPhilip McLoone - Collaborator - University of GlasgowSrinivasa Vittal Katikireddi - Collaborator - University of GlasgowStefan Siebert - Collaborator - University of Glasgow

CPRD868

People with the common skin condition psoriasis more commonly have tendon problems and up to a third will develop psoriatic arthritis (PsA), which is characterised by inflammation of tendons and joints. While there has been progress in understanding the underlying immune mechanisms in psoriasis and PsA, it remains unclear why some people with psoriasis develop tendon problems and PsA while others do not.

People with psoriasis have an increased risk of tendon problems and up to a third will develop psoriatic arthritis (PsA) which is characterised by inflammation of tendons and joints. There have been advances in understanding the underlying immunology of these conditions which has led to effective treatments. However, many patients do not respond to these therapies and it remains unclear why some people with psoriasis develop these tendon problems and PsA while many others do not. It is likely that factors other than immune dysfunction may also play an important role in precipitating these musculoskeletal issues in people with psoriasis. Fluoroquinolone antibiotics have been shown to have a direct effect on tendons and are associated with an increased risk of tendon injury and rupture in the general population but again it is not known why this only affects some people.

10/02/2021

Release