Uppsala University

Academic Institute

OFHS240246

Obesity and hormone-based medications, like birth control pills and medication for treatment of menopausal symptoms, have both been linked to an increased risk of several serious diseases, including various types of cancer, stroke, and heart attack. The aim of this study is to understand why only some people develop health problems related to obesity or hormone medications, while others do not. We will look at the effects of these factors both separately and together, to see whether the combination of the two increases the risk even more. We will look at how the risk of disease differs between men and women, how the risk changes with increasing age, and how this is all connected to our genes, the material we inherit from our parents at birth, carrying the instructions that shape who we are, from our physical traits to how our bodies function. By finding out what causes these differences, we hope to learn more about why some people are more vulnerable to these health effects. Obesity and hormone-based medications are common risk factors for several serious diseases, but they do not affect everyone the same way. About half of all adults are overweight, and most women will use birth control pills or menopausal treatments at some phase during their life. However, not everyone appears to be affected in the same way. This suggests that other factors, like age, sex, and genetic factors, play a role in how obesity and hormone-based medication eventually influence disease risk. Understanding these differences is important if we want to figure out who is most at risk and why, which could help in preventing these diseases.

This study will help doctors understand who is more likely to develop health problems related to obesity or hormone-based medications. Right now, it is unclear why some people get sick while others do not, even if they have the same risk factors. By figuring out who is more at risk, we can make sure those people get the right care before they develop serious health problems. For women using hormone-based medications like birth control or menopausal treatments, this study will also reduce uncertainty. Knowing who is more likely to have problems will help doctors give better advice and make these medications safer and more effective for everyone. Ultimately, the study could lead to fewer people getting sick, less stress for those taking these medications, and better overall health for the population.

Public Health Research

06/08/2025

04/06/2025

TRE