HDR Gateway logo
HDR Gateway logo

Bookmarks

Incidence, Prevalence of Multiple Sclerosis in CPRD – Burden of Mortality, Infection and Cancer Among Patients With Multiple Sclerosis

Safe People

Organisation name

Roche

Organisation sector

Commercial

Applicant name(s)

Pam Jayia - Chief Investigator - RocheBoris Addow - Corresponding Applicant - RocheAna Ruigomez - Collaborator - CEIFELuis Alberto Garcia Rodriguez - Collaborator - CEIFEOscar Fernandez-Cantero - Collaborator - CEIFE

Safe Projects

Project ID

CPRD886

Lay summary

Multiple sclerosis (MS) is the most common cause of serious neurological disability in young adults. It is estimated that more than 2.3 million people have MS worldwide. MS has a chronic course that carries a heavy family, economic and social services burden on a permanent basis.This burden has multiple factors and reflects both the impact of MS relapses on patients’ health, quality of life and productivity and the effects of various diseases associated with MS. Patients with MS also have an underlying predisposition to infections. Both systemic and central nervous system infections are major complications of MS. We wish to investigate the characteristics of patients with MS and explore the occurrence and type of infections and cancer among them compared to the general population (free of MS).

Technical summary

Multiple Sclerosis (MS) is estimated to affect to more than 2.3 million people worldwide. The chronic course of MS is associated with a high morbidity burden, and an underlying predisposition to infections, including opportunistic infections. Both systemic and central nervous system (CNS) infections are major complications of MS.

Latest approval date

12/01/2021

Safe Data

Dataset(s) name

HES Accident and Emergency

HES Admitted Patient Care

ONS Death Registration Data

Patient Level Townsend Score

Safe Setting

Access type

Release