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Understanding clusters and mechanisms of complex multimorbidity in people with common allergic conditions

Safe People

Organisation name

London School of Hygiene and Tropical Medicine

Organisation sector

Academic Institute

Applicant name(s)

Sinead Langan - Chief Investigator - London School of Hygiene & Tropical Medicine ( LSHTM )Amy Mulick - Corresponding Applicant - London School of Hygiene & Tropical Medicine ( LSHTM )Alasdair Henderson - Collaborator - London School of Hygiene & Tropical Medicine ( LSHTM )Aziz Sheikh - Collaborator - University of EdinburghDavid McAllister - Collaborator - University of GlasgowDavid Prieto-Merino - Collaborator - London School of Hygiene & Tropical Medicine ( LSHTM )Dorothea Nitsch - Collaborator - London School of Hygiene & Tropical Medicine ( LSHTM )Jennifer Quint - Collaborator - Imperial College LondonKathryn Mansfield - Collaborator - London School of Hygiene & Tropical Medicine ( LSHTM )Liam Smeeth - Collaborator - London School of Hygiene & Tropical Medicine ( LSHTM )Ronan Lyons - Collaborator - Swansea UniversitySpiros Denaxas - Collaborator - University College London ( UCL )

Safe Projects

Project ID

CPRD894

Lay summary

Asthma and eczema are common allergic diseases. Asthma can make breathing difficult, and eczema causes red, itchy skin. Existing evidence has linked asthma and eczema to other diseases, including heart disease and broken bones. Links between asthma/eczema and other diseases may may be due to the biological mechanisms of asthma and eczema themselves, the side effects of the drugs used to manage eczema/asthma, or perhaps something related to having asthma and eczema (like reduced ability to exercise, due to breathing difficulties in asthma or sweat increasing itch in eczema, or longterm sleep problems due to itch).

Technical summary

Our study aims to characterise known and novel clusters of multimorbidity (known and novel) in common allergic disorders (asthma and atopic eczema).

Latest approval date

06/01/2021

Safe Data

Dataset(s) name

Patient Level Index of Multiple Deprivation

Practice Level Index of Multiple Deprivation

Safe Setting

Access type

Release