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Genetic determinants of distinct body mass index trajectories to young-adulthood obesity
Safe People
Organisation name
University of Bristol
Organisation sector
Academic Institute
Applicant name(s)
Laura Howe
Stephanie Page
Amanda Hughes
William Johnson
Thomas Norris
Safe Projects
Project ID
B3910
Lay summary
Different body mass index (BMI) trajectories that result in obesity may have diverse aetiologies and health consequences, yet this heterogeneity is poorly understood. Previous research in the ALSPAC cohort has identified patterns of BMI development between ages 7 and 24 (Norris et al). Analyses using these patterns showed that people who have high and stable BMI across childhood may have lower cardiometabolic disease risk than individuals who do not become overweight or obese until late adolescence. How genetic factors relate to these patterns of BMI development is not known.
Public benefit statement
aetiological understanding of BMI trajectories
Latest approval date
25/10/2021