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Genetic determinants of distinct body mass index trajectories to young-adulthood obesity

Safe People

Organisation name

University of Bristol

Organisation sector

Academic Institute

Applicant name(s)

Laura HoweStephanie PageAmanda HughesWilliam JohnsonThomas Norris

Safe Projects

Project ID

B3910

Lay summary

Different body mass index (BMI) trajectories that result in obesity may have diverse aetiologies and health consequences, yet this heterogeneity is poorly understood. Previous research in the ALSPAC cohort has identified patterns of BMI development between ages 7 and 24 (Norris et al). Analyses using these patterns showed that people who have high and stable BMI across childhood may have lower cardiometabolic disease risk than individuals who do not become overweight or obese until late adolescence. How genetic factors relate to these patterns of BMI development is not known.

Public benefit statement

aetiological understanding of BMI trajectories

Latest approval date

25/10/2021