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Student Project The role of the human gut microbiome in cancer aetiology

Safe People

Organisation name

University of Bristol

Organisation sector

Academic Institute

Applicant name(s)

Kaitlin WadeMiss Rebecca Scanlan

Safe Projects

Project ID

B3858

Lay summary

A burgeoning field of research has highlighted the role of the human microbiome in mediating a range of pathologies including obesity, metabolic syndrome, inflammatory disorders, and alterations in stress responses and behaviour. Furthermore, the progression of certain cancers may be driven by microbial interactions and possess distinct microbial signatures which may contribute towards tumour inflammation. The gut microbiome of an individual has potential to be modified in order to improve health outcomes given recent therapeutic developments.

Public benefit statement

The gut microbiome is a modifiable risk factor for disease that may have clinical importance in terms of breast cancer incidence and progression, and potentially facilitate therapeutic development to improve health and reduce the burden of the disease.

Latest approval date

26/08/2021