University of Bristol

Academic Institute

Matthew SudermanDr Paul YousefiAlec McKinlay

B3907

DNA methylation (DNAm) in neurological tissue is often difficult or impossible to use for observational studies, as sample collection must usually occur post-mortem. Studies interested in DNAm changes in brain related to disease outcomes or exposures commonly rely on DNAm measured in less invasive surrogate tissue, like blood, which typically have poorly characterised relationships with the target tissue DNAm levels of interest.

This is a pilot investigation to determine if we should seek funds to generate a larger and more refined DNA methylation dataset of matching brain and blood samples. Such a dataset would increase our ability to explain epigenetic variation in brain from blood samples.

25/10/2021