Bookmarks
Capturing epigenetic variation in the brain using blood
Safe People
Organisation name
University of Bristol
Organisation sector
Academic Institute
Applicant name(s)
Matthew Suderman
Dr Paul Yousefi
Alec McKinlay
Safe Projects
Project ID
B3907
Lay summary
DNA methylation (DNAm) in neurological tissue is often difficult or impossible to use for observational studies, as sample collection must usually occur post-mortem. Studies interested in DNAm changes in brain related to disease outcomes or exposures commonly rely on DNAm measured in less invasive surrogate tissue, like blood, which typically have poorly characterised relationships with the target tissue DNAm levels of interest.
Public benefit statement
This is a pilot investigation to determine if we should seek funds to generate a larger and more refined DNA methylation dataset of matching brain and blood samples. Such a dataset would increase our ability to explain epigenetic variation in brain from blood samples.
Latest approval date
25/10/2021