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MR-PREG Consortium 26-07-2021

Safe People

Organisation name

University of Bristol

Organisation sector

Academic Institute

Applicant name(s)

Amy TaylorCarolina BorgesDeborah LawlorAlice CarterMarwa Al ArabNancy McbrideAna Luiza SoaresQian YangAlba Fernandez-SanlesFanny Kilpi

Safe Projects

Project ID

B3844

Lay summary

ALSPAC contributes to a group of studies called MR-PREG which aims to investigate the impact of maternal exposures during pregnancy (such as BMI, smoking, blood pressure) on pregnancy complications, perinatal outcomes and later offspring outcomes. MR-PREG uses genetic data to explore whether associations between maternal exposures and these outcomes are likely to be causal.

Public benefit statement

There are already several papers in progress from the initial MR-PREG analyses. This work will be important for identifying the impact of maternal exposures during pregnancy and possible targets for intervention (e.g. healthy BMI ranges for pregnant women to prevent preterm birth).

Latest approval date

20/09/2021