University of Cambridge

Academic Institute

B3873

This project will use longitudinal neuroimaging to study the network features of structural and functional connectivity that characterize subclinical psychotic experiences (PEs) and their development over time. Previous work with the ALSPAC cohort has shown that compared to healthy controls, subjects with a history of PEs show schizophrenia-like topological changes in structural connectivity (Drakesmith et al. 2015). Moreover, the presence of PEs has been associated with mild changes in frontoparietal network configuration during a working memory task (Fonville et al. 2015).

We believe that this work will lead to a greater understanding of the brain connectivity signatures of psychotic experiences as well as the biological patterns underlying them. From an academic perspective, we believe that this work will result in the publication of one or more articles in a high-level academic journals.

23/09/2021