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Identifying markers for brain signatures of adolescent depression and depression risk

Safe People

Organisation name

University of Edinburgh

Organisation sector

Academic Institute

Applicant name(s)

Heather WhalleyMiss Amelia Edmonson-StaitDr Alex Kwong

Safe Projects

Project ID

B3860

Lay summary

We currently have another proposal (B3421) investigating the brain signatures of adolescent depression and depression risk. In order to fully examine this project, we are running some initial analysis to define the most robust markers of depression across adolescence. From preliminary analysis and other research, we have found that trajectories of depressive symptoms may be robust markers for some brain signatures. Additionally, these trajectories could mediate the relationship between early risk factors and later brain signatures. Therefore, we are running additional analysis on the trajectories to validate these findings and we will examine them with the following methods. Please note, we already have access to the data, this is a student project using that data.

Public benefit statement

Shed light on biological mechanisms underpinning depression

Latest approval date

13/09/2021