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Genome wide association study of progression from impaired fasting glucose to type 2 diabetes
Safe People
Organisation name
University of Bristol
Organisation sector
Academic Institute
Applicant name(s)
April Hartley
Professor Kate Tilling
Professor George Davey Smith
Dr Venexia Walker
Safe Projects
Project ID
B3872
Lay summary
Pre-diabetes is a condition where blood glucose levels are elevated above normal, but below the threshold to be defined as type 2 diabetes. It is estimated that 70% of those meeting the criteria for pre-diabetes will eventually progress to type 2 diabetes, which is a chronic, incurable condition associated with various other comorbidities. It is therefore important to understand why some individuals progress from pre-diabetes to type 2 diabetes, so that we can develop interventions to stop this happening. We therefore aim to identify the genetic basis for why some individuals progress from pre-diabetes to type 2 diabetes.
Public benefit statement
The ALSPAC data will contribute to a larger GWAS meta-analysis which will hopefully identify genes involved in progression from pre-diabetes to type 2 diabetes. The resulting summary statistics will also be used for two-sample Mendelian randomization analyses to identify non-genetic risk factors. Identifying risk factors for progression from pre-diabetes to diabetes may aid the development of interventions to prevent diabetes onset in those at high risk.
Latest approval date
20/09/2021