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Identifying genetic and environmental factors underpinning complex trait variation in humans

Safe People

Organisation name

Westlake University (China)

Organisation sector

Academic Institute

Applicant name(s)

Jian YangFei-Fei ChengMSDr Ting Qi

Safe Projects

Project ID

B3841

Lay summary

Most human traits (including diseases) are influenced by many genetic and environmental factors. Population-based genetic studies have been proven valuable for identifying genetic factors responsible for the traits and for predicting an individual's risk of developing a disease. However, a widening knowledge gap exists between cutting-edge genetics research and current clinical practices. Besides the genetic factors, an increasing number of lifestyle and environmental factors that can trigger and exacerbate a condition have been documented. Thus, it is essential to collect well-organised genetic data and health records to identify the genetic and environmental factors and to yield clinically actionable disease predictors.

Public benefit statement

The findings of this project are crucial to deepen the understanding of the disease etiology and prevention, are of great importance for public health, and are also in concordance with the ALSPAS's stated purpose. The combination of new data and new methods will take us into an era of personalized and precision treatments based on an individual's gene, environment, and lifestyle, which has the potential to have a significant impact on health care.

Latest approval date

24/08/2021