University of Bristol

Academic Institute

Gemma SharpDr Kate NorthstoneProf Nic Timpson

B3857

Accumulating online discussions suggest some women have experienced menstrual changes after receiving the COVID-19 vaccine. This is important and potentially concerning, as a large proportion of people menstruate and menstrual health is increasingly recognised as an important indicator and determinant of broader health and quality of life. The extent, nature, and mechanism of COVID-19 vaccine-related menstrual changes is currently unclear. The menstrual cycle is regulated by a complex interplay of hormones that can interact with the immune system to influence menstrual bleeding and premenstrual symptoms; vaccines cause huge immune disruptions and so could plausibly affect menstrual features. Questions about menstruation were added to the most recent questionnaire sent to ALSPAC participants. In this project, we will explore 1) the prevalence of different types of vaccine-associated menstrual disruptions, 2) demographic and life history factors associated with experiencing menstrual disruptions, 3) through future ALSPAC planned follow-ups, the duration of menstrual disruptions and future reproductive health outcomes.

The MHRA has identified this as an area of interest. Our results will be fed directly back to them, as well as published in a peer-reviewed journal articles.

02/09/2021