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What are smoking initiation SNPs capturing Exploring pleiotropy in genetic analyses of smoking-related exposures
Safe People
Organisation name
University of Bristol
Organisation sector
Academic Institute
Applicant name(s)
Zoe Reed
Professor Marcus Munafò
Professor George Davey Smith
Dr Jasmine Khouja
Dr Robyn Wootton
Dr Thomas Richardson
Safe Projects
Project ID
B3843
Lay summary
Recent studies have suggested that genetic variants associated with smoking behaviours may actually be influencing outcomes such as risk taking behaviours. This may pose a problem for analyses which assume that these genetic variants are associated with smoking behaviours and not with other outcomes. Therefore, it is important to ascertain whether this is the case. We aim to assess whether genetic variants for smoking behaviours are also associated with other outcomes. We have conducted analyses in a separate cohort (the UK Biobank) which provides evidence to support this. However, we want to replicate analyses to see whether this is also the case in a different sample (ALSPAC) where selection into the UK Biobank might be different in ALSPAC and where we can also test associations in children prior to smoking. Our results will help inform future studies using these genetic variants for smoking behaviours.
Public benefit statement
This research will lead to a better understanding of the genetic influences on smoking behaviours and may help us to understand which measures are better used in different studies if pleiotropic effects are observed.
Latest approval date
09/08/2021