University of Bristol

Academic Institute

Jie ZhengDr Jamie RobinsonProfessor Tom Gaunt

B3819

Genetic colocalization is a genetic epidemiology method that have been widely applied to understand the role of molecular traits on human diseases. However, the method has the assumption that there is only one association signal exist in the test region, which is not always the case. In this project, we aim to refine the method by integrating conditional analysis approach (GCTA-COJO) with colocalization approach. We will develop the method using C++ and apply it to a wide range of molecular traits and disease outcomes. The ALSPAC genotype data will be used as the reference panel for the application of the novel method.

PWCoCo, the new method we plan to develop, will be a leading method that change the gameset of genetic colocalization approach. The application of PWCoCo will bring causal links between genes and diseases, which some of the genes could be drug targets for novel drugs.

08/07/2021