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Using Instruments for Selection to Adjust for Selection Bias in Mendelian Randomization

Safe People

Organisation name

University of Bristol

Organisation sector

Academic Institute

Applicant name(s)

Apostolos GkatzionisProfessor Kate TillingDr Kate NorthstoneDr Jon Heron

Safe Projects

Project ID

B3838

Lay summary

Biomedical research is often hindered by the presence of missing data. For example, missing data can occur due to study participants' unwillingness to disclose sensitive information about themselves (e.g. refusing to answer questions related to their mental health, alcohol consumption or drug use). In our research, we develop novel statistical methodologies to account for missing data, using available information on traits that affect a participant's willingness to provide full data but not otherwise affecting the outcome of an applied study. We hope to illustrate our method by using the ALSPAC dataset to estimate the true prevalence of alcoholism, depression, smoking and self-harm, as well as assessing the effects of obesity and education on these traits.

Public benefit statement

This work will showcase our new method to adjust for selection bias. If our method proves to be effective, its use will aid researchers working on applications where selection bias is suspected.

Latest approval date

02/08/2021