University of Bristol

Academic Institute

Giulia MancanoDr Gemma SharpDr Thanh T. Hoang

B3809

The detriment of maternal smoking on offspring is well known while the biological mechanism regulating the relationship are not fully understood. Epigenetic profile has emerged as a potential link between the two. Sustained maternal smoking during pregnancy, here defined as smoking past the first trimester, has been associated with deferentially methylated CpG sites in the offspring (1-6) and a dose-response effect might also be plausible (2, 4, 7).

To expand the portfolio of evidence of the impact of prenatal smoking on offspring DNA-methylation by investigating a series of smoking-related exposures.

21/06/2021