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Examining the genetic architecture of depression in and around pregnancy in the ALSPAC study
Safe People
Organisation name
University of Bristol
Organisation sector
Academic Institute
Applicant name(s)
Alex KwongRuxin LuoDr Rebecca PearsonDr Hannah SallisMs Holly Fraser
Safe Projects
Project ID
B3806
Lay summary
Depression is a common and complex disease, influenced by both genetic and environmental factors, with heritability estimated to be from 31% to 42%. However, a recent genome-wide association study meta-analysing data on 807,553 individuals from three largest GWAS studies identified 102 independent variants and 269 genes associated with depression. This result suggests that depression is a polygenetic trait and enables researchers to use these polygenic risk scores to investigate how genetic liability for depression manifests over the life course.
Public benefit statement
Further understanding of the aetiology of depression
Latest approval date
07/06/2021