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Birth order and cord blood DNA methylation
Safe People
Organisation name
University of Bristol
Organisation sector
Academic Institute
Applicant name(s)
Giulia Mancano
Dr Gemma Sharp
Sebastian (Shaobo) Li
Safe Projects
Project ID
B3810
Lay summary
Birth order has strong correlations with developmental and environmental aspects. Birth order is a presumed factor affecting multiple diseases including leukemia (1, 2, 3), atopy (4), type I diabetes (5), non-Hodgkin lymphoma (6) and synovial sarcoma (7). Moreover, first born subjects have unique in utero characteristics including less sufficient placentation, higher estrogen levels, and lower insulin sensitivity. Birth order might therefore play a role in shaping DNA methylation pattern and influence the initiation of the diseases mentioned above.
Public benefit statement
Build evidence to elucidate the effect of birth order on neonatal DNA methylation and investigate its possible implication on system development and disease risk.
Latest approval date
21/06/2021