University of Bristol

Academic Institute

Giulia MancanoDr Gemma SharpSebastian (Shaobo) Li

B3810

Birth order has strong correlations with developmental and environmental aspects. Birth order is a presumed factor affecting multiple diseases including leukemia (1, 2, 3), atopy (4), type I diabetes (5), non-Hodgkin lymphoma (6) and synovial sarcoma (7). Moreover, first born subjects have unique in utero characteristics including less sufficient placentation, higher estrogen levels, and lower insulin sensitivity. Birth order might therefore play a role in shaping DNA methylation pattern and influence the initiation of the diseases mentioned above.

Build evidence to elucidate the effect of birth order on neonatal DNA methylation and investigate its possible implication on system development and disease risk.

21/06/2021