Bookmarks
The association between epigenetic prediction signatures of complex traits and health outcomes in ALSPAC
Safe People
Organisation name
University of Bristol
Organisation sector
Academic Institute
Applicant name(s)
Ryan Langdon
Chloë Fabbricatore
Matt Suderman
Safe Projects
Project ID
B3808
Lay summary
Modelling complex phenotypes using DNA methylation (DNAm) is becoming increasingly common in Epigenetic Epidemiology. This process often includes the use of weighted DNAm “scores” to differentiate between classes of categorical exposures, estimate continuous exposures and/or predict disease outcomes. The reason DNAm can do this is because it bridges the gap between your biology and your environment; one function of DNAm is that it will work to alter gene expression in response to an environmental stimulus. Accordingly, it can be thought of as a “biosocial archive”.
Public benefit statement
Generating evidence to support downstream use (or not) of DNA methylation to improve how epidemiologically-relevant phenotypes are defined
Latest approval date
22/06/2021