University of Toronto

Academic Institute

Tomas PausZhijie LiaoMSc

B3771

Testosterone has an influence on social behavior and cognition, such as brain response to faces. Testosterone exposure during puberty can modulate the effects of adult testosterone on brain response to faces. Genetic variants contribute to inter-individual variations in testosterone levels, and a polygenic score can be used as a summary index of such genetic variants. We will use the ALSPAC dataset to investigate (1) the relationship between average testosterone exposure during puberty and polygenic score for testosterone; (2) interplay between the polygenic score for testosterone and adult testosterone in brain response to faces. In addition, we will also explore the relationships between the polygenic score for testosterone and brain structure.

24/05/2021