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Association of diet and physical activity with serum metabolites and cardiovascular disease risk in adolescents from the ALSPAC

Safe People

Organisation name

University of Bristol

Organisation sector

Academic Institute

Applicant name(s)

Laura JohnsonMr Eduard Martinez

Safe Projects

Project ID

B3776

Lay summary

In this study I am going to look at how different lifestyle factors, like foods eaten, timing or frequency of eating, physical activity, sedentary behaviours and their timing or location, combine together to create an overall behavioural pattern score that indicates whether adolescents have good health. It has been previously found that a combination of factors is more important for health compared with single factors alone. I also plan to use a new, reproducible laboratory technique, known as metabolomics, to record over 220 measures of blood that indicate a range of metabolic processes. This will help to find out in much more detail than ever before how behaviour leads to better cardiovascular health via metabolic pathways. When it is known more about the pathway that leads from lifestyle to disease it will be easier to predict who will stay healthy and who will not from their behaviours.

Public benefit statement

Identifying the metabolic intermediates between poor health behaviours and long-term metabolic risk has the potential to offer objective methods for monitoring health, looking at responses to intervention and preventing long-term risk of cardiometabolic disease.

Latest approval date

13/05/2021