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Biological markers to study genetics environment and how they influence mental health
Safe People
Organisation name
University College London
Organisation sector
Academic Institute
Applicant name(s)
Elvira Bramon
Dr Eirini Zartaloudi
Safe Projects
Project ID
B3767
Lay summary
WHAT ARE THE CAUSES OF PSYCHOSIS? Psychotic disorders including schizophrenia and bipolar disorder are potentially severe conditions affecting about 3% of the population, and constitute a major economic challenge throughout the world. A range of effective antipsychotic medications and psychological therapies are available, but about one in every three patients do not benefit from them. Antipsychotics can cause a range of common and serious side effects such as sleepiness, shaking, sexual dysfunction, obesity and diabetes.
Public benefit statement
Understanding the neurobiological mechanisms underlying psychotic disorders is key to develop new treatments. Understanding better the genetic and environmental influences on response to antipsychotic drugs will help us optimise how we prescribe these medications.
Latest approval date
13/05/2021