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Analysis of the role of HLA-type on T-cell state in Covid-19 infection
Safe People
Organisation name
Brigham and Women's Hospital
Organisation ID
grid.62560.37
Applicant name(s)
Soumya Raychaudhuri
Safe Projects
Project ID
DAA103_EGA
Lay summary
T-cells are a special part of the immune system that patrol the body looking for foreign invaders such as viruses. If they find them, they trigger an immune response to fight them off. The human immune system uses genes called “Major Histocompatibility Complexes” or MHC to display proteins on the surface of cells for T-cells to find using a special MHC scanner gene called a T-cell receptor. We want to better understand how differences in MHC genes between people influence their ability to respond to infections including COVID-19 and how it shapes the set of T-cell receptors that are present in a person. We will use the data from the single-cell COVID-19 dataset to figure out which versions of the MHC genes each person has and will see if we can relate that to the versions of the T-cell receptors they have. This can teach us about how T-cell receptors bind to proteins displayed on MHC genes which will help scientists to better understand how our immune systems find and fight off viruses and other foreign invaders.
Request category type
Research
Other approval committees
NIHR BioResource Data Access Committee
Latest approval date
23/02/2022
Safe Data
Dataset(s) name
Data sensitivity level
De-Personalised
Legal basis for provision of data under Article 6
(e) processing is necessary for the performance of a task carried out in the public interest or in the exercise of official authority vested in the controller;
Lawful conditions for provision of data under Article 9
(j) processing is necessary for archiving purposes in the public interest, scientific or historical research purposes or statistical purposes in accordance with Article 89(1) based on Union or Member State law which shall be proportionate to the aim pursued, respect the essence of the right to data protection and provide for suitable and specific measures to safeguard the fundamental rights and the interests of the data subject.
Common Law Duty of Confidentiality
The individual to whom the information relates has consented
National data opt-out applied?
No
Request frequency
One-off
Safe Setting
Access type
Release