Manchester University NHS Foundation Trust

CQC Registered Health or/and Social Care provider

Ruth Gottstein

NHS Blood and Transplant Trustees Fund GrantNICU Endowment Fund

nnrd50

Exchange Blood Transfusion (EBT) is now rare but remains an emergency treatment mainly for very high or rapid rising serum bilirubin levels that are not responding to treatment with phototherapy. There is very little known about how often the procedure is performed currently in the UK & Ireland, or the complication rate. This information would be useful to inform medical practice and for counselling parents in the future. The study aims to ascertain the current incidence and complication rates (including death) of EBT, as well as the practical difficulties of performing an EBT. There is insufficient understanding of the effect of current EBT procedures on the baby’s clotting and platelet count, and therefore uncertainty about when the baby should have additional blood component support. Systematic collection of routinely available laboratory data will enable better recommendations for future practice and neonatal exchange red cell component development. A better understanding of the current incidence of adverse metabolic outcomes as a result of EBT, as well as incidence of morbidity and mortality, will be invaluable to guidefuture practice

We need to obtain better evidence about the safety and effectiveness of the Exchange Blood Transfusion procedure. In the past, this procedure was much more common and most of the evidence for it was produced by looking back through case notes. We now need up-to-date information which can tell us more about how many new born babies receive EBT and what the current risks and side effects are.

REC reference: 13/NW/0063CAG Reference: 14/CAG/1010

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