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The Genetics of Osteoarthritis (GO) Consortium - GWAS meta-analysis

Safe People

Organisation name

Helmholtz Zentrum München

Organisation ID

grid.4567.0

Applicant name(s)

Eleftheria Zeggini

Safe Projects

Project ID

DAA114

Lay summary

More than 300 million people in the world have osteoarthritis, and live with painful joints in old age. We cannot currently cure osteoarthritis, we only treat the pain with painkillers and use surgery to install artificial joints. Your genes play a large role in how likely you are to have the disease. It is not caused by a single gene but by a large number of genes with small effects that interact together. To find these genes, we have created a global alliance of researchers, the Genetics of Osteoarthritis consortium. We have combined the genetic information from many groups all over the world to compare 180,000 patients and 650,000 individuals without osteoarthritis. We have found more than 100 places in the genome where changes to the genetic code affect the risk of osteoarthritis. For many of these, we have also found genes that could explain how the disease works, and help develop treatments. In this proposal, we want to add the osteoarthritis patients and controls from the NIHR BioResource to our analysis. This time, we will include even more populations from all over the world. This way, we can detect additional genes involved in the disease and increase our hope to discover a treatment.

Request category type

Research

Other approval committees

NIHR BioResource Data Access Committee

Latest approval date

14/03/2022

Safe Data

Dataset(s) name
Data sensitivity level

De-Personalised

Legal basis for provision of data under Article 6

(e) processing is necessary for the performance of a task carried out in the public interest or in the exercise of official authority vested in the controller;

Lawful conditions for provision of data under Article 9

(j) processing is necessary for archiving purposes in the public interest, scientific or historical research purposes or statistical purposes in accordance with Article 89(1) based on Union or Member State law which shall be proportionate to the aim pursued, respect the essence of the right to data protection and provide for suitable and specific measures to safeguard the fundamental rights and the interests of the data subject.

Common Law Duty of Confidentiality

The individual to whom the information relates has consented

National data opt-out applied?

No

Request frequency

One-off

Safe Setting

Access type

Release