University of Cambridge

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James Lee

DAA086

Genetic studies have found many regions in our DNA that contribute to autoimmune disease. A lot of these regions function in CD4 T cells. Exactly how tiny changes in DNA at these sites lead to disease, however, is largely unknown. In our last study, we looked at DNA changes at 13 regions linked to autoimmune diseases. Donors who carried one copy of the risk variant and one copy of the non-risk variant provided samples. Using these, we found out how risk variants affect CD4 T cells. This helped us uncover a protective pathway that is disrupted in multiple diseases. Our experiments provide data across the whole genome (not just the 13 regions). If we knew whether the donors had any risk variants at other disease regions, we could then use our data for future studies. This has two knock-on effects. First, it means we can study other risk variants without needing more samples. Second, it speeds up our efforts to find new disease pathways. This maximises the value of our data. It also help us find new drug targets faster. This is why we have asked for more genetic data from the donors who helped with our study. We will not be able to identify the donors from this data.

Research

NIHR BioResource Data Access Committee

22/09/2021

De-Personalised

(e) processing is necessary for the performance of a task carried out in the public interest or in the exercise of official authority vested in the controller;

(j) processing is necessary for archiving purposes in the public interest, scientific or historical research purposes or statistical purposes in accordance with Article 89(1) based on Union or Member State law which shall be proportionate to the aim pursued, respect the essence of the right to data protection and provide for suitable and specific measures to safeguard the fundamental rights and the interests of the data subject.

The individual to whom the information relates has consented

No

One-off

Release