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Lymphoma in inflammatory bowel disease including the risk associated with immunosuppression and patient outcomes
Safe People
Newcastle upon Tyne Hospitals NHS Foundation Trust
grid.420004.2
Keir Packard
Safe Projects
DAA106
Many studies report a small increase in cancer risk in patients with inflammatory bowel disease (IBD). This may be linked to inflammation itself or to drugs that are used to treat IBD. Although the risk is low, it is important to identify risk factors for cancer so that anyone at risk may be identified and the safest treatment selected for them. One of the cancers associated with IBD is lymphoma, a type of blood cancer developing from lymph node cells (lymphocytes). Lymphoma is a serious and sometimes fatal diagnosis. A recent study has suggested that the risk of lymphoma is six times higher in IBD patients taking thiopurines compared to patients who do not take these drugs. The specific types of lymphoma and the risk factors associated with it have not been studied in a UK IBD population. We propose to identify patients in the IBD BioResource who have a diagnosis of lymphoma. We will determine what type of lymphoma occurred and analyse any factors in their lifestyle, their type of IBD and how it was treated, that may have increased risk of lymphoma. This will help us understand the reason that lymphoma developed and how to reduce the risk in future patients. We would then analyse detailed clinical information in this group including the treatment they received for IBD, the type of lymphoma, how they were treated and the outcomes of treatment. The overarching aim of the study will be to identify individuals with IBD who are most at risk of developing lymphoma, and personalising their treatment to reduce this risk as much as possible.
Research
NIHR BioResource Data Access Committee
23/11/2021
Safe Data
De-Personalised
(e) processing is necessary for the performance of a task carried out in the public interest or in the exercise of official authority vested in the controller;
(j) processing is necessary for archiving purposes in the public interest, scientific or historical research purposes or statistical purposes in accordance with Article 89(1) based on Union or Member State law which shall be proportionate to the aim pursued, respect the essence of the right to data protection and provide for suitable and specific measures to safeguard the fundamental rights and the interests of the data subject.
The individual to whom the information relates has consented
No
One-off
Safe Setting
Release