Newcastle Upon Tyne Hospitals NHS Foundation Trust

Janet BerringtonDr Chris GalePer Torp SangildRene Liang ShenSabita UthayaGorm GriesenJulie FormanNicholas Embleton

Novo Nordic FoundationNewcastle Upon Tyne Hospitals NHS Foundation Trust

No

620A-4C6C-97D0-AC4D-22DC-D8FE

Necrotising enterocolitis (NEC) is a key cause of mortality and morbidity in preterm infants. Early antibiotic use has been shown to impact on rates of NEC, with data suggesting that receipt in the first days after birth is protective, but long duration has adverse impact on NEC rates. We aim to use the large UK dataset of preterm births known as the The National Neonatal Research Database (NNRD) to further delineate this relationship. The NNRD holds data on 'every' preterm neonate admitted in the United Kingdom in a link anonymised fashion, allowing exploration of the role of antibiotics in NEC development in a much bigger population than previously explored.

This data will help clinical decisions around early antibiotic receipt (empirical) in preterm infants immediately after birth. Around 3% of all infants are born at below 32 weeks, when risk of NEC development is highest. Better understanding of the role of early antibiotics in modifying NEC risk would have significant global impact.

22/12/2022

(a) the data subject has given consent to the processing of his or her personal data for one or more specific purposes;

Not applicable

Section 251 support

One-off

Release

Only population level data will be published, ie risks of NEC given exposures to antibiotics