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Early antibiotic use and incidence of necrotising enterocolitis in very preterm infants: a UK based observational study using routinely recorded data
Safe People
Organisation name
Newcastle Upon Tyne Hospitals NHS Foundation Trust
Applicant name(s)
Janet Berrington
Dr Chris Gale
Per Torp Sangild
Rene Liang Shen
Sabita Uthaya
Gorm Griesen
Julie Forman
Nicholas Embleton
Funders/ Sponsors
Novo Nordic FoundationNewcastle Upon Tyne Hospitals NHS Foundation Trust
DEA accredited researcher?
No
Safe Projects
Project ID
620A-4C6C-97D0-AC4D-22DC-D8FE
Lay summary
Necrotising enterocolitis (NEC) is a key cause of mortality and morbidity in preterm infants. Early antibiotic use has been shown to impact on rates of NEC, with data suggesting that receipt in the first days after birth is protective, but long duration has adverse impact on NEC rates. We aim to use the large UK dataset of preterm births known as the The National Neonatal Research Database (NNRD) to further delineate this relationship. The NNRD holds data on 'every' preterm neonate admitted in the United Kingdom in a link anonymised fashion, allowing exploration of the role of antibiotics in NEC development in a much bigger population than previously explored.
Public benefit statement
This data will help clinical decisions around early antibiotic receipt (empirical) in preterm infants immediately after birth. Around 3% of all infants are born at below 32 weeks, when risk of NEC development is highest. Better understanding of the role of early antibiotics in modifying NEC risk would have significant global impact.
Latest approval date
22/12/2022
Safe Data
Dataset(s) name
Legal basis for provision of data under Article 6
(a) the data subject has given consent to the processing of his or her personal data for one or more specific purposes;
Lawful conditions for provision of data under Article 9
Not applicable
Common Law Duty of Confidentiality
Section 251 support
Request frequency
One-off
Safe Setting
Access type
Release
How has data been processed to enhance privacy?
Only population level data will be published, ie risks of NEC given exposures to antibiotics