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C-MORE study

Safe People

Organisation name

University of Oxford

Organisation sector

Academic Institute

Applicant name(s)

Betty Raman

Safe Projects

Project ID

eDRIS-2122-0097

Lay summary

Although COVID-19 mostly affects the lungs, some people can develop damage to other organs. The symptoms of this disease can continue for months after the infection. The purpose of this study is to understand the effects of COVID-19 on the health of the lungs, heart, brain, liver and kidney and assess its effects on the quality of life, mental health and exercise capacity of affected individuals over a period of 12 months after the infection and compare these with those of people who have not had COVID-19. We would like to study up to 616 patients who have been infected with COVID-19 and 62 people who have not been infected (control group). We will use the control group as a benchmark to compare against the results of the infected group. Participants will be invited to attend up to 3 visits around three, six and twelve months after the infection. Controls who have not shown COVID-19 symptoms will attend only one visit. The visits will include magnetic resonance (MRI) (a system used in radiology to form pictures of the organs and the way they work) as well as assessments of breathing, exercise capacity and mental health. This research is organized by the Division of Cardiovascular Medicine at the University of Oxford and is funded by NIHR Oxford Biomedical Research Centre.

Latest approval date

15/07/2021

Safe Data

Dataset(s) name

PHOSP Clinical Data

Safe Setting

Access type

Release