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CCU030: Examining potential factors underlying the increased risk of severe COVID-19 experienced by people with intellectual and developmental disabilities
Safe People
Organisation name
University of Glasgow
Organisation sector
Academic Institute
Applicant name(s)
Craig Melville
Sub-licence arrangements (if any)?
No
Safe Projects
Project ID
CCU030
Lay summary
People living with intellectual and developmental disabilities (i.e. intellectual disabilities and/or autism) are more likely to be admitted to hospital and die from infection with COVID-19. We do not know why people living with intellectual and developmental disabilities experience poorer outcomes following infection with COVID-19. These poorer outcomes from COVID-19 infection may be caused by people living with intellectual and developmental disabilities: • having higher rates of health problems • being more likely to have two or more serious health problems (multimorbidity) • commonly taking several different medications (polypharmacy). This distinct pattern of health problems experienced by people living with intellectual and developmental disabilities may increase the risk of poorer outcomes from COVID-19 infection. For example, epilepsy is more commonly experienced by people living with intellectual and developmental disabilities, and epilepsy is a known risk factor for premature death from respiratory infections, like COVID-19. Lower rates of vaccination and the type of vaccine that people receive might also influence the higher risk of poorer outcomes.
Public benefit statement
We will investigate whether the complex health problems experienced by people living with intellectual and developmental disabilities and vaccination patterns are linked to poorer COVID-19 outcomes. We hope that the results of this study will help improve outcomes of people living with intellectual and developmental disabilities who are infected with COVID-19. Visit the BHF Data Science Centre website for more detailed information about project outputs. https://bhfdatasciencecentre.org/projects/ccu030/
Technical summary
This project accessed the following datasets within the Trusted Research Environment(s) for CVD-COVID-UK / COVID-IMPACT: - ENGLAND: - Civil Registration - Deaths - Covid-19 Second Generation Surveillance System - Covid-19 UK Non-hospital Antibody Testing Results - Covid-19 UK Non-hospital Antigen Testing Results - COVID-19 Vaccination Status - GPES Data for Pandemic Planning and Research (COVID-19) - Hospital Episode Statistics Admitted Patient Care - Hospital Episode Statistics Critical Care - Medicines dispensed in Primary Care (NHSBSA data) - Secondary Care Prescribed Medicines (EPMA)
Latest approval date
22/10/2021
Safe Data
Dataset(s) name
Data sensitivity level
De-Personalised
Safe Setting
Access type
TRE