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Immune receptor repertoire analysis of viral infections at single-cell level

Safe People

Organisation name

Mahidol University

Organisation ID

grid.10223.32

Applicant name(s)

Dr. Anunya Opasawatchai

Safe Projects

Project ID

DAA124_EGA

Lay summary

Looking at Immune receptors during viral infections at a single-cell level White blood cells called T and B cells have a special role in helping our bodies fight infection. Structures, called receptors, are situated on the surface of each cell. When your body has an infection, these receptors stick or cling on to parts of the bacteria or viruses that have invaded your body. These immune receptors can be different between each person because it depends on what infections your body has had to fight during your lifetime. However, despite people having fought different infections, research has shown that many immune receptors will be similar, and these are known as public T or B cell receptors. This study wants to use a special, new genetic technique to learn more about how these public T and B cell receptors behave in people who have been infected with various viruses, including SARS-CoV2, dengue fever, influenza virus and HIV. We will collect this information (data) from public resources, including SARS-CoV2 sample data from the NIHR BioResource. We will use computational methods to identify common receptors and then aim to test this research in our lab to understand how these receptors bind in these infections. We hope our research will help towards developing new treatments to prevent and help fight against new viral infections.

Request category type

Research

Other approval committees

NIHR BioResource Data Access Committee

Latest approval date

16/03/2022

Safe Data

Dataset(s) name
Data sensitivity level

De-Personalised

Legal basis for provision of data under Article 6

(e) processing is necessary for the performance of a task carried out in the public interest or in the exercise of official authority vested in the controller;

Lawful conditions for provision of data under Article 9

(j) processing is necessary for archiving purposes in the public interest, scientific or historical research purposes or statistical purposes in accordance with Article 89(1) based on Union or Member State law which shall be proportionate to the aim pursued, respect the essence of the right to data protection and provide for suitable and specific measures to safeguard the fundamental rights and the interests of the data subject.

Common Law Duty of Confidentiality

The individual to whom the information relates has consented

National data opt-out applied?

No

Request frequency

One-off

Safe Setting

Access type

Release