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The role of genetics in liver disease during pregnancy

Safe People

Organisation name

University College London

Organisation ID

grid.83440.3b

Applicant name(s)

Julia Zöllner

Safe Projects

Project ID

DAA133

Lay summary

The study has the following aims: Aim 1. To investigate the genetic cause of intrahepatic cholestasis of pregnancy (ICP), the most common liver disorder of pregnancy, in women in the NIHR bioresource. ICP can cause problems with the health of the unborn baby, e.g. preterm birth and stillbirth, and affected women can have serious liver disease in later life. Aim 2. To find out whether ICP-associated genetic changes result in other liver diseases such as cirrhosis in affected women and their families. The combination of medical records and genomic data provides a powerful tool to address these aims.

Request category type

Research

Other approval committees

NIHR BioResource Data Access Committee

Latest approval date

22/06/2022

Safe Data

Dataset(s) name
Data sensitivity level

De-Personalised

Legal basis for provision of data under Article 6

(e) processing is necessary for the performance of a task carried out in the public interest or in the exercise of official authority vested in the controller;

Lawful conditions for provision of data under Article 9

(j) processing is necessary for archiving purposes in the public interest, scientific or historical research purposes or statistical purposes in accordance with Article 89(1) based on Union or Member State law which shall be proportionate to the aim pursued, respect the essence of the right to data protection and provide for suitable and specific measures to safeguard the fundamental rights and the interests of the data subject.

Common Law Duty of Confidentiality

The individual to whom the information relates has consented

National data opt-out applied?

No

Request frequency

One-off

Safe Setting

Access type

Release