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PROJECT WITHDRAWN - CCU048: COVID-19 infection, vaccination and psychosis risk
Safe People
Organisation name
King's College London
Organisation sector
Academic Institute
Applicant name(s)
Dominic Oliver
Sub-licence arrangements (if any)?
No
Safe Projects
Project ID
CCU048
Lay summary
There is strong evidence that infections with certain viruses making it more likely for someone to develop psychotic disorders, such as schizophrenia. Since the start of the COVID-19 pandemic, we have seen more people seeking treatment for psychosis symptoms in the UK. We currently do not know whether this is because of COVID-19 and its potential effects on the brain. Similarly, there have been some cases of psychosis after people have received COVID-19 vaccines. In this study, we will test whether people are more likely to develop psychosis after positive COVID-19 tests and after vaccination. There have been reports of individual patients who have developed psychosis shortly after COVID-19 infection and after vaccination. However, we do not know whether these cases are representative of the whole population. Through this project, we will be able to assess the relationship between COVID-19 infection/vaccination and psychosis that will be more meaningful to the whole population.
Public benefit statement
If people are more likely to develop psychosis after COVID-19 infection and/or vaccination, this would suggest that there may be more psychosis cases than usual in the coming years. This would provide evidence to support increased funding to prevention and early intervention of psychosis in the NHS. Visit the BHF Data Science Centre website for more detailed information about project outputs. https://bhfdatasciencecentre.org/projects/ccu048/
Technical summary
This project accessed the following datasets within the Trusted Research Environment(s) for CVD-COVID-UK / COVID-IMPACT: - ENGLAND: - Civil Registration - Deaths - COVID-19 SARI-Watch (formerly CHESS) - Covid-19 Second Generation Surveillance System - Covid-19 UK Non-hospital Antibody Testing Results - Covid-19 UK Non-hospital Antigen Testing Results - COVID-19 Vaccination Status - GPES Data for Pandemic Planning and Research (COVID-19) - Hospital Episode Statistics Accident and Emergency - Hospital Episode Statistics Admitted Patient Care - Hospital Episode Statistics Outpatients - Medicines dispensed in Primary Care (NHSBSA data) - Secondary Care Prescribed Medicines (EPMA)
Latest approval date
09/08/2022
Safe Data
Dataset(s) name
Data sensitivity level
De-Personalised
Safe Setting
Access type
TRE