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Effect of genetic variants associated with risk for inflammatory disease on immune cell phenotype and function
Safe People
Wellcome Sanger Institute
grid.10306.34
Harriet Banks
Safe Projects
DAA129
In the UK, at least 300,000 people have inflammatory bowel disease (IBD; which includes Crohn's disease and ulcerative colitis). IBD leads to chronic inflammation in parts of the digestive system and it is thought to occur due to an abnormal response to harmless bacteria in the gut. This response is believed to be a consequence of a complex interaction between environmental and genetic factors. Our group and others have used genetic association studies (GWAS) to identify over 240 regions of the genome that increase susceptibility to IBD. Some of these regions are within well-known genes that interfere with the immunological response. However, most of them have no defined mechanism of action. Understanding how these variants contribute to someone developing IBD is important for our biological understanding of disease mechanisms and the development of novel therapies. In this project we aim to investigate the mechanisms by which four genetic variants increase the risk of developing IBD. These genetic variants are likely to play a role in the production and/or response to inflammatory mediators important in IBD. We will analyse changes in the gene expression and function of immune cells comparing individuals carrying the risk variants with those carrying the non-risk variants. Our studies aim to increase our understanding of how genetic variants affect the individual’s immune function and might contribute to their increased risk for developing IBD.
Research
NIHR BioResource Data Access Committee
25/05/2022
Safe Data
De-Personalised
(e) processing is necessary for the performance of a task carried out in the public interest or in the exercise of official authority vested in the controller;
(j) processing is necessary for archiving purposes in the public interest, scientific or historical research purposes or statistical purposes in accordance with Article 89(1) based on Union or Member State law which shall be proportionate to the aim pursued, respect the essence of the right to data protection and provide for suitable and specific measures to safeguard the fundamental rights and the interests of the data subject.
The individual to whom the information relates has consented
No
One-off
Safe Setting
Release