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CCU020: Evaluation of antithrombotic use and COVID-19 outcomes
Safe People
Organisation name
University College London
Organisation sector
Academic Institute
Applicant name(s)
Alex Handy
Sub-licence arrangements (if any)?
No
Safe Projects
Project ID
CCU020
Lay summary
Antithrombotics are blood thinning medications that are used to treat a range of cardiovascular diseases. Atrial fibrillation (AF) is one such disease, and is the most common disturbance of heart rhythm and a common cause of stroke. In individuals who have AF, antithrombotics are used to lower stroke risk. However, around a third of those with AF are not on the most effective type of antithrombotic or take no medication at all. New evidence is emerging that individuals already taking antithrombotic medication (whether for AF or for another disease) may have improved outcomes if they become infected with COVID-19. However, the evidence for a protective association between antithrombotics and COVID-19 remains inconclusive. This project will, therefore, explore three questions: 1. How many individuals in the UK with AF are not currently on antithrombotic medication? 2. Do individuals with AF taking antithrombotic medication prior to COVID-19 infection have better outcomes (e.g. hospitalisation, mortality) than those that don’t? 3. What factors (e.g. location, age) are associated with a lack of antithrombotic medication in individuals with AF?
Public benefit statement
In addressing these questions, this project will create the software to automatically evaluate antithrombotic use in near real-time across the whole UK population. This will provide the information to help ensure individuals with AF are given the most effective treatments and confirm whether antithrombotics offer some protection against COVID-19.
Latest approval date
08/05/2021
Safe Data
Dataset(s) name
Data sensitivity level
De-Personalised
Safe Setting
Access type
TRE
Safe Outputs
Link to research outputs