University College London

Academic Institute

No

CCU020

Antithrombotics are blood thinning medications that are used to treat a range of cardiovascular diseases. Atrial fibrillation (AF) is one such disease, and is the most common disturbance of heart rhythm and a common cause of stroke. In individuals who have AF, antithrombotics are used to lower stroke risk. However, around a third of those with AF are not on the most effective type of antithrombotic or take no medication at all. New evidence is emerging that individuals already taking antithrombotic medication (whether for AF or for another disease) may have improved outcomes if they become infected with COVID-19. However, the evidence for a protective association between antithrombotics and COVID-19 remains inconclusive. This project will, therefore, explore three questions: 1. How many individuals in the UK with AF are not currently on antithrombotic medication? 2. Do individuals with AF taking antithrombotic medication prior to COVID-19 infection have better outcomes (e.g. hospitalisation, mortality) than those that don’t? 3. What factors (e.g. location, age) are associated with a lack of antithrombotic medication in individuals with AF?

In addressing these questions, this project will create the software to automatically evaluate antithrombotic use in near real-time across the whole UK population. This will provide the information to help ensure individuals with AF are given the most effective treatments and confirm whether antithrombotics offer some protection against COVID-19. Visit the BHF Data Science Centre website for more detailed information about project outputs. https://bhfdatasciencecentre.org/projects/ccu020/

This project accessed the following datasets within the Trusted Research Environment(s) for CVD-COVID-UK / COVID-IMPACT: - ENGLAND: - Civil Registration - Deaths - COVID-19 SARI-Watch (formerly CHESS) - Covid-19 Second Generation Surveillance System - Covid-19 UK Non-hospital Antibody Testing Results - Covid-19 UK Non-hospital Antigen Testing Results - COVID-19 Vaccination Adverse Reaction - COVID-19 Vaccination Status - GPES Data for Pandemic Planning and Research (COVID-19) - Hospital Episode Statistics Accident and Emergency - Hospital Episode Statistics Admitted Patient Care - Hospital Episode Statistics Critical Care - Hospital Episode Statistics Outpatients - ICNARC: Intensive Care National Audit and Research Centre - Medicines dispensed in Primary Care (NHSBSA data) - NICOR – NACRM: National Audit of Cardiac Rhythm Management - Secondary Care Prescribed Medicines (EPMA) - Secondary Uses Services Payment By Results - Sentinel Stroke National Audit Programme Clinical Dataset

08/05/2021

De-Personalised

TRE