This dataset forms part of the OPTIMising therapies, discovering therapeutic targets and AI-assisted clinical management for patients Living with complex multimorbidity (OPTIMAL) NIHR funded programme.

Multimorbidity is common, especially in older adults, and is associated with an increased risk of hospital admissions and poorer outcomes. Caring for older adults with complex multimorbidity presenting acutely to hospital is challenging, as guidelines often do not focus on multimorbidity and older adults are especially susceptible to adverse effects from polypharmacy.

PIONEER has curated this dataset of 15,950 patients aged 65 and over with multimorbidity who were acutely admitted to hospital and had an inpatient stay. It contains longitudinal data on serial physiology readings, frailty scores, blood results, medications, comorbidities, drug allergies, treatments, procedures, and mortality outcomes up to a year post-discharge. While this subset focuses on older adults, a full dataset covering all ages is also available.

Geography: The West Midlands (WM) has a population of 6 million & includes a diverse ethnic & socio-economic mix. UHB is one of the largest NHS Trusts in England, providing direct acute services & specialist care across four hospital sites, with 2.2 million patient episodes per year, 2750 beds & > 120 ITU bed capacity. UHB runs a fully electronic healthcare record (PICS; Birmingham Systems), a shared primary & secondary care record (Your Care Connected) & a patient portal “My Health”.

Data set availability: Data access is available via the PIONEER Hub for projects which will benefit the public or patients. This can be by developing a new understanding of disease, by providing insights into how to improve care, or by developing new models, tools, treatments, or care processes. Data access can be provided to NHS, academic, commercial, policy and third sector organisations. Applications from SMEs are welcome. There is a single data access process, with public oversight provided by our public review committee, the Data Trust Committee. Contact pioneer@uhb.nhs.uk or visit www.pioneerdatahub.co.uk for more details.

All data uses should name both PIONEER and the NIHR Optimal programme in data outputs. This will be specified in the Data Licensing Agreement.

Available supplementary data: Matched controls; ambulance and community data. Unstructured data (images). We can provide the dataset in OMOP and other common data models and can build synthetic data to meet bespoke requirements.

Available supplementary support: Analytics, model build, validation & refinement; A.I. support. Data partner support for ETL (extract, transform & load) processes. Bespoke and “off the shelf” Trusted Research Environment build and run. Consultancy with clinical, patient & end-user and purchaser access/ support. Support for regulatory requirements. Cohort discovery. Data-driven trials and “fast screen” services to assess population size.