Natriuretic peptides are special proteins produced by the heart, with the two key types being BNP and NT-proBNP. NT-proBNP is particularly useful in managing heart failure and assessing the risk of heart problems. This marker is not just for heart failure; studies have suggested that NT-proBNP levels during the acute phase of sepsis may be a useful indicator of higher risk of long-term impairments in physical function and muscle strength in sepsis survivors. This dataset asset, created by PIONEER for the National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre (BRC) grant, includes detailed demographics, comorbidities, admission reasons, and care journeys for 254 ICU patients aged 65 and over. It contains serial physiological and blood test measurements reflecting disease severity, imaging, investigative results, treatments, and outcomes. This dataset is a valuable resource for evaluating the clinical utility of NT-proBNP as a prognostic marker for complications and mortality in older critically ill patients. A full dataset covering all ages is also available upon request. Geography: The West Midlands has a population of 6 million & includes a diverse ethnic & socio-economic mix. UHB is one of the largest NHS Trusts in England, providing direct acute services & specialist care across four hospital sites, with 2.2 million patient episodes per year, 2750 beds & > 120 ITU bed capacity. UHB runs a fully electronic healthcare record (EHR) (PICS; Birmingham Systems), a shared primary & secondary care record (Your Care Connected) & a patient portal “My Health”. Data set availability: Data access is available via the PIONEER Hub for projects which will benefit the public or patients. This can be by developing a new understanding of disease, by providing insights into how to improve care, or by developing new models, tools, treatments, or care processes. Data access can be provided to NHS, academic, commercial, policy and third sector organisations. Applications from SMEs are welcome. There is a single data access process, with public oversight provided by our public review committee, the Data Trust Committee. Contact pioneer@uhb.nhs.uk or visit www.pioneerdatahub.co.uk for more details. Available supplementary data: Matched controls; ambulance and community data. Unstructured data (images). We can provide the dataset in OMOP and other common data models and can build synthetic data to meet bespoke requirements. Available supplementary support: Analytics, model build, validation & refinement; A.I. support. Data partner support for ETL (extract, transform & load) processes. Bespoke and “off the shelf” Trusted Research Environment build and run. Consultancy with clinical, patient & end-user and purchaser access/ support. Support for regulatory requirements. Cohort discovery. Data-driven trials and “fast screen” services to assess population size.