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Moorfields AMD Dataset 002

Population Size

9,925

People

Population Size statistic card

Years

2001

Years statistic card

Associated BioSamples

Other

Associated BioSamples statistic card

Geographic coverage

https://www.geonames.org/2648147/great-britain.html

Geographic coverage statistic card

Lead time

2-6 months

Lead time statistic card

Summary

The AMD Dataset at Moorfields Eye Hospital NHS Foundation Trust is a longitudinal dataset consisting of routinely-collected imaging and clinical metadata from patients receiving treatment for age-related macular degeneration (AMD) from 2001 to the present

Documentation

The AMD Dataset encompasses all patients who have received at least one injection of either Lucentis (ranibizumab) or Eylea (aflibercept) to treat age-related macular degeneration (AMD) at Moorfields Eye Hospital - a leading provider of eye health services in the UK and a world-class centre of excellence for ophthalmic research and education.

These therapies began at Moorfields in 2007, however, the dataset will include any imaging or clinical metadata that is available for these patients prior to that time (for example in patients who were initially monitored for the early or intermediate forms of this disease prior to receiving treatment). Also of note, this dataset will include data from both eyes in each case - for example, it will include data from fellow eyes that are not receiving injections. For these reasons, the dataset will include longitudinal data from a mixture of eyes with both “dry” and “wet” AMD.

Clinical metadata includes information regarding:

  • patient demographics
  • visual acuities (predominantly measured with Early Treatment Diabetic Retinopathy Study (ETDRS) charts)
  • diabetic retinopathy grading
  • intravitreal therapies and ocular surgeries

Additional information is provided in the ‘technical details’ tab.

The AMD dataset includes eye imaging modalities, such as:

  • Optical coherence tomography (CSO, Heidelberg, Optos, Topcon, Zeiss)
  • Colour fundus photographs (Topcon, Zeiss)
  • Ultra-wide field photographs (Optos, Zeiss)
  • Iris photographs (CSO, Zeiss)
  • Keratoscope topography (CSO)
  • Infrared photographs (Heidelberg, Topcon, Zeiss)
  • Fluorescein angiography (Heidelberg, Optos, Topcon, Zeiss)
  • Indocyanine green angiography (Heidelberg, Optos, Topcon)
  • Fundus autofluorescence (Heidelberg, Optos, Zeiss)

Imaging data from CSO is subject to additional approvals.

As of July 2024, the dataset consisted of 12,641 eyes receiving Lucentis or Eylea for AMD, 220,219 injection episodes, and 2,943,338 ophthalmic images. This is the largest single centre database from patients with AMD and covers more than a decade of follow-up for these patients.

Dataset type

Health and disease

Dataset sub-type

Not applicable

Dataset population size

9925

Keywords

Observations

Observed Node

Disambiguating Description

Measured Value

Measured Property

Observation Date

Persons

19,785 Eyes with 2,943,338 Images 12,641 Eyes with 220,219 Injections (Lucentis/Eylea)

9925

Patients

01 Jul 2024

Provenance

Purpose of dataset collection

Study

Collection source setting

Clinic, Secondary care - Accident and Emergency, Secondary care - Outpatients, Secondary care - In-patients

Patient pathway description

The dataset is representative of the entire pathway for patients receiving treatment for age-related macular degeneration (AMD) at Moorfields Eye Hospital NHS Foundation Trust .

Image contrast

Not stated

Biological sample availability

Other

Structural Metadata

Details

Publishing frequency

Continuous

Version

4.0.0

Modified

08/10/2024

Coverage

Start date

01/03/2001

Time lag

1-2 weeks

Minimum age range

48

Maximum age range

102

Follow-up

10 Years

Accessibility

Language

en

Controlled vocabulary

SNOMED CT, DM+D, NHS NATIONAL CODES

Format

CSV, Image

Data Access Request

Dataset pipeline status

Not available

Time to dataset access

2-6 months

Access method category

TRE/SDE

Access service description

INSIGHT is developing its data access environment for researchers. INSIGHT releases anonymised data, under strict data licence arrangements, to external secure environments, subject to appropriate due diligence and contracting.

Jurisdiction

GB-GBN

Data use limitation

General research use

Data use requirements

Project-specific restrictions

Data Controller

Moorfields Eye Hospital NHS Foundation Trust

Dataset Types: Health and disease


Collection Sources: Clinic, Secondary care - Accident and Emergency, Secondary care - Outpatients, Secondary care - In-patients

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