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Moorfields AMD Dataset 002

Population Size

9,925

People

Years

2001

Associated BioSamples

Other

Geographic coverage

https://www.geonames.org/2648147/great-britain.html

Lead time

Not applicable

Summary

The AMD Dataset at Moorfields Eye Hospital NHS Foundation Trust is a longitudinal dataset consisting of routinely-collected imaging and clinical metadata from patients receiving treatment for age-related macular degeneration (AMD) from 2001 to the present

Documentation

The AMD Dataset encompasses all patients who have received at least one injection of either Lucentis (ranibizumab) or Eylea (aflibercept) to treat age-related macular degeneration (AMD) at Moorfields Eye Hospital - a leading provider of eye health services in the UK and a world-class centre of excellence for ophthalmic research and education.

These therapies began at Moorfields in 2007, however, the dataset will include any imaging or clinical metadata that is available for these patients prior to that time (for example in patients who were initially monitored for the early or intermediate forms of this disease prior to receiving treatment). Also of note, this dataset will include data from both eyes in each case - for example, it will include data from fellow eyes that are not receiving injections. For these reasons, the dataset will include longitudinal data from a mixture of eyes with both “dry” and “wet” AMD.

Clinical metadata includes information regarding:

  • patient demographics
  • visual acuities (predominantly measured with Early Treatment Diabetic Retinopathy Study (ETDRS) charts)
  • diabetic retinopathy grading
  • intravitreal therapies and ocular surgeries

Additional information is provided in the ‘technical details’ tab.

The AMD dataset includes eye imaging modalities, such as:

  • Optical coherence tomography (CSO, Heidelberg, Optos, Topcon, Zeiss)
  • Colour fundus photographs (Topcon, Zeiss)
  • Ultra-wide field photographs (Optos, Zeiss)
  • Iris photographs (CSO, Zeiss)
  • Keratoscope topography (CSO)
  • Infrared photographs (Heidelberg, Topcon, Zeiss)
  • Fluorescein angiography (Heidelberg, Optos, Topcon, Zeiss)
  • Indocyanine green angiography (Heidelberg, Optos, Topcon)
  • Fundus autofluorescence (Heidelberg, Optos, Zeiss)

Imaging data from CSO is subject to additional approvals.

As of July 2024, the dataset consisted of 12,641 eyes receiving Lucentis or Eylea for AMD, 220,219 injection episodes, and 2,943,338 ophthalmic images. This is the largest single centre database from patients with AMD and covers more than a decade of follow-up for these patients.

Dataset type
Health and disease
Dataset sub-type
Not applicable
Dataset population size
9925

Keywords

Eylea, Ophthalmology, Referral, Vision, Topcon, ranibizumab, aflibercept, AMD, Wet AMD, Wet, Eye, MEH, Left, Right, Injection, Diagnosis, Eye condition, Laterality, Ophthalmology, Dry AMD, Topcon, OCT, Colour photo, Age-Related Macular Degeneration, Surgery, Modality, Heidelberg, Macular, Protocol, Cataract, Glaucoma, Diabetes, DMO, DR, Ocular, Optic, Lucentis, Eye drop, IVT, Treatment, VA, Visual Acuity, Zeiss

Observations

Observed Node
Disambiguating Description
Measured Value
Measured Property
Observation Date

Persons

19,785 Eyes with 2,943,338 Images 12,641 Eyes with 220,219 Injections (Lucentis/Eylea)

9925

Patients

01 Jul 2024

Provenance

Purpose of dataset collection
Study
Collection source setting
Clinic, Secondary care - Accident and Emergency, Secondary care - Outpatients, Secondary care - In-patients
Patient pathway description
The dataset is representative of the entire pathway for patients receiving treatment for age-related macular degeneration (AMD) at Moorfields Eye Hospital NHS Foundation Trust .
Image contrast
Not stated
Biological sample availability
Other

Structural Metadata

Details

Publishing frequency
Continuous
Version
4.0.0
Modified

08/10/2024

Coverage

Start date

01/03/2001

Time lag
1-2 weeks
Minimum age range
48
Maximum age range
102
Follow-up

10 Years

Accessibility

Language
en
Controlled vocabulary
SNOMED CT, DM+D, NHS NATIONAL CODES
Format
CSV, Image

Data Access Request

Dataset pipeline status
Not available
Time to dataset access
Not applicable
Access method category
TRE/SDE
Access service description

INSIGHT is developing its data access environment for researchers. INSIGHT releases anonymised data, under strict data licence arrangements, to external secure environments, subject to appropriate due diligence and contracting.

Jurisdiction
GB-GBN
Data use limitation
General research use
Data use requirements
Project-specific restrictions
Data Controller
Moorfields Eye Hospital NHS Foundation Trust

Dataset Types: Health and disease


Collection Sources: Clinic, Secondary care - Accident and Emergency, Secondary care - Outpatients, Secondary care - In-patients