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AMPLE (AMyloid imaging for Phenotyping LEwy body dementia)

Population Size

0

People

Years

2013

Associated BioSamples

None/not available

Geographic coverage

United Kingdom

Lead time

Data only

Summary

The principle aim of AMPLE is to undertake amyloid PET imaging in Lewy Body Dementia (LBD) and Alzheimer's disease (AD) participants and investigate the distribution of amyloid burden in LBD relative to AD and controls at baseline. A further aim is to determine the relationship between amyloid levels at baseline, clinical features of the disease, other imaging changes and subsequent clinical course in follow up.  Primary analysis would divide LBD patients into high and low amyloid burden with pa

Documentation

All Participants: Age 60+. Sufficient English to carry out cognitive testing. Controls: MMSE greater than or equal to 26. Lewy Body/AD Dementia: MMSE greater than or equal to 12. Meet criteria for probable LBD/AD. If taking anti-cholinesterase drugs or memantine, stable for at least 3 months. Presence of reliable informant sufficient to provide information for informant rated scales.Concurrent major psychiatric illness (e.g. major depression). Severe physical illness or comorbidity that may limit ability to fully participate in study. Past history of excess alcohol intake. Past history of neurological illness including stroke. Contra-indications for MR or PET. Psychotropic medications which may significantly interfere with cognitive testing (anti- dementia drugs not an exclusion criteria). Controls: memory complaints or signs/ symptoms of dementia. Past history of Parkinson's disease. Psychotropic medications which may significantly interfere with cognitive testing (anti- dementia drugs not an exclusion criteria). Controls: memory complaints or signs/ symptoms of dementia. Past history of Parkinson's disease. Alzheimer's patients: Past history of Parkinson's disease. All Participants: Contra-indications for MR or PET imaging.Past history of excessive alcohol intake. Past history of other neurological illness including, but not limited to stroke, intracerebral pathology. Psychotropic and other medications which may significantly interfere with cognitive testing (including but not limited to sedative antidepressants, benzodiazepines except low when used as hypnotics, centrally acting anticholinergic drugs). Use of anti dementia drugs (eg anti-cholinesterase drugs or memantine) is not an exclusion criterion. A relevant history of severe drug allergy or hypersensitivity. Have ever participated in an experimental study with an amyloid targeting agent (e.g. anti-amyloid immunotherapy, or γ-secretase inhibitor) unless it can be documented that the subject received only placebo during the course of the trial. Receiving any investigational medications, or participation in a trial with investigational medications within the last 30 days. A radiopharmaceutical imaging or treatment procedure within 7 days prior to the study imaging session.

Dataset type
Health and disease, Imaging types, Omics
Dataset sub-type
Not applicable

Keywords

Dementia, neurological, parkinsons, Alzheimers, Lewy body, Neuroimaging

Provenance

Purpose of dataset collection
Study
Biological sample availability
None/not available

Structural Metadata

Details

Publishing frequency
Continuous
Version
1.0.0
Modified

17/02/2025

Coverage

Start date

02/04/2013

Time lag
Not applicable
Geographic coverage
United Kingdom
Minimum age range
60
Maximum age range
100
Follow-up
Unknown

Accessibility

Language
en
Alignment with standardised data models
OTHER
Controlled vocabulary
OTHER
Format
CSV

Data Access Request

Dataset pipeline status
Available
Access method category
TRE/SDE
Access service description
The Data Portal runs its analysis environment through a virtual desktop infrastructure accessible via VMWare software. By analysing the data in the virtual desktop environment you are working on DPUK's servers – meaning there is no physical transfer of data to researchers. The processing capacity enables you to work with large numbers of records and integrate these with the other data modalities that exist in the DPUK cohorts. This solution also offers researchers the freedom to conduct their analyses anywhere with an internet connection.
Data Controller
Newcastle university
Data Processor
Dementias Platform UK

Dataset Types: Health and disease, Imaging types, Omics


Collection Sources: