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Factors Predicting Serum HLA Antibody Persistence or Decline in Kidney Transplant Patients
Population Size
1,000
People
Years
2015 - 2021
Associated BioSamples
None/not available
Geographic coverage
West Midlands
Lead time
Variable
Summary
This research project investigates the dynamics of donor-specific HLA antibodies (DSA) in kidney transplant patients awaiting transplantation. The primary aim is to develop a predictive tool that identifies whether patients' HLA antibodies are likely to persist or decline over time.
Documentation
In the UK, over 8,000 patients are on the waiting list for kidney transplants. Approximately 26% of these patients are classified as highly sensitised, which significantly extends their median waiting time to around six years. The presence of HLA antibodies complicates the transplant process, as potential donors with corresponding HLA mismatches are avoided. Understanding the factors that influence the persistence or decline of HLA antibodies can aid in making informed clinical decisions and enhance the management of waiting list patients. This information is crucial for optimizing patient management and improving the chances of successful transplantation for highly sensitized patients—those with high levels of HLA antibodies who face longer waiting times and fewer compatible donor options.
Dataset type
Health and disease
Dataset sub-type
Not applicable
Dataset population size
1000
Observations
Observed Node | Disambiguating Description | Measured Value | Measured Property | Observation Date |
|---|---|---|---|---|
Persons | 1000 | Count | 20 Feb 2025 |
Provenance
Image contrast
Not stated
Biological sample availability
None/not available
Structural Metadata
Details
Publishing frequency
Static
Version
1.0.0
Modified
18/02/2025
Citation Requirements
SDE014
Coverage
Start date
01/01/2015
End date
31/12/2021
Time lag
Not applicable
Geographic coverage
West Midlands
Accessibility
Language
en
Alignment with standardised data models
LOCAL
Controlled vocabulary
LOCAL
Format
SQL
Data Access Request
Dataset pipeline status
Not available
Access rights
Information Governance and Ethics - West Midlands Secure Data Environment (https://westmidlandssde.nhs.uk/information-governance-and-ethics)
Time to dataset access
Variable
Access request cost
Please email wmsde@uhb.nhs.uk
Access method category
TRE/SDE
Access service description
Data Request Process - West Midlands Secure Data Environment (https://westmidlandssde.nhs.uk/research/data-request)