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Factors Predicting Serum HLA Antibody Persistence or Decline in Kidney Transplant Patients

Population Size

1,000

People

Population Size statistic card

Years

2015 - 2021

Years statistic card

Associated BioSamples

None/not available

Associated BioSamples statistic card

Geographic coverage

West Midlands

Geographic coverage statistic card

Lead time

Variable

Lead time statistic card

Summary

This research project investigates the dynamics of donor-specific HLA antibodies (DSA) in kidney transplant patients awaiting transplantation. The primary aim is to develop a predictive tool that identifies whether patients' HLA antibodies are likely to persist or decline over time.

Documentation

In the UK, over 8,000 patients are on the waiting list for kidney transplants. Approximately 26% of these patients are classified as highly sensitised, which significantly extends their median waiting time to around six years. The presence of HLA antibodies complicates the transplant process, as potential donors with corresponding HLA mismatches are avoided. Understanding the factors that influence the persistence or decline of HLA antibodies can aid in making informed clinical decisions and enhance the management of waiting list patients. This information is crucial for optimizing patient management and improving the chances of successful transplantation for highly sensitized patients—those with high levels of HLA antibodies who face longer waiting times and fewer compatible donor options.

Dataset type

Health and disease

Dataset population size

1000

Observations

Observed Node

Disambiguating Description

Measured Value

Measured Property

Observation Date

Persons

1000

Count

20 Feb 2025

Provenance

Image contrast

Not stated

Biological sample availability

None/not available

Structural Metadata

Details

Publishing frequency

Static

Version

1.0.0

Modified

18/02/2025

Citation Requirements

SDE014

Coverage

Start date

01/01/2015

End date

31/12/2021

Time lag

Not applicable

Geographic coverage

West Midlands

Accessibility

Language

en

Alignment with standardised data models

LOCAL

Controlled vocabulary

LOCAL

Format

SQL

Data Access Request

Dataset pipeline status

Not available

Access rights

Information Governance and Ethics - West Midlands Secure Data Environment (https://westmidlandssde.nhs.uk/information-governance-and-ethics)

Time to dataset access

Variable

Access request cost

Please email wmsde@uhb.nhs.uk

Access method category

TRE/SDE

Access service description

Data Request Process - West Midlands Secure Data Environment (https://westmidlandssde.nhs.uk/research/data-request)

Dataset Types: Health and disease

Collection Sources: