C-reactive protein (CRP) is the classical acute-phase protein produced by the liver at rates regulated by pro-inflammatory cytokines, notably IL-6. Acute phase CRP production is non-specific but generally reflects the extent and severity of whatever infective, inflammatory, traumatic and neoplastic conditions have triggered it (Pepys, M. B. & Hirschfield, G. M. J. Clin. Invest. 111, 1805-1812 (2003). CRP binds specifically to dead or dying cells and then activates complement, leading to enhanced inflammation and exacerbation of pre-existing tissue damage (Griselli, M. et al. J. Exp. Med. 190, 1733-1739 (1999). Large amounts of CRP in the blood can also increase damage to tissues that are already injured. CRP may thus contribute to disease severity and death in COVID-19.

Circulating CRP values in COVID-19 patients are closely associated with disease activity, severity and outcome (for example: L. Yan et al. (2020)

However, the published studies are of moderate size with only one or few CRP measurements per patient.

In this OMOP dataset, we present longitudinal CRP measurements for a cohort of over 4500 hospitalised COVID-19 patients, from admission to discharge, including severity of disease, co-morbidities, treatments given, complications, ITU admissions and patient outcomes.

PIONEER geography: The West Midlands (WM) has a population of 5.9 million & includes a diverse ethnic & socio-economic mix.

EHR. UHB is one of the largest NHS Trusts in England, providing direct acute services & specialist care across four hospital sites, with 2.2 million patient episodes per year, 2750 beds & an expanded 250 ITU bed capacity during COVID. UHB runs a fully electronic healthcare record (EHR) (PICS Birmingham Systems), a shared primary & secondary care record (Your Care Connected) & a patient portal “My Health”.

Scope: All hospitalised patients admitted to Queen Elizabeth Hospital, Birmingham with positive SARS-Cov2 tests reported, transformed into an extended set of tables based on OMOP. The dataset includes highly granular patient demographics & co-morbidities taken from ICD-10 & SNOMED-CT codes. Serial, structured data pertaining to process of care including timings, admissions, escalation of care to ITU, discharge outcomes, physiology readings (heart rate, blood pressure, AVPU score and others), blood results (especially C-Reactive Protein (CRP) measurements) and drug prescribing and administration data.

Available supplementary data: Matched controls ambulance, synthetic data.

Available supplementary support: Analytics, Model build, validation & refinement A.I. Data partner support for ETL (extract, transform & load) process, Clinical expertise, Patient & end-user access, Purchaser access, Regulatory requirements, Data-driven trials, “fast screen” services.