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Feasibility testing of digital platform to capture PROs for CAR-T precision cellular therapies

Population Size

Not reported
Population Size statistic card

Years

2019 - 2025

Years statistic card

Associated BioSamples

None/not available

Associated BioSamples statistic card

Geographic coverage

West Midlands

Geographic coverage statistic card

Lead time

Variable

Lead time statistic card

Summary

Development and feasibility testing of a digital platform to capture patient reported outcomes (PROs) for CAR-T precision cellular therapies. This dataset uses retrospective clinical data collected in the electronic health record of all patients with haematological malignancies that have received CAR-T therapy as an input for artificial intelligence (AI) based prediction models for the early detection of adverse outcomes following CAR-T cell therapies.

Documentation

The field of precision cellular therapy is forecast to undergo rapid expansion in the coming decade and there is an urgent need for evidence-based tools, co-produced with patients, to better support the growing number of individuals with haematologic malignancies who will receive these potentially curative treatments. The novelty of Chimeric Antigen Receptor T-cell (CAR-T) therapies, the unique and potentially severe toxicities associated with these treatments, and emerging evidence of long-term and late-effects of treatment mean effective symptom monitoring is key to maximising treatment benefit and ensuring patient safety. Development of predictive models that include ePRO data have been developed for other cancers and therapies; however, these systems may not be appropriate for monitoring the distinctive symptom profiles associated with CAR-T cellular therapy, providing the warrant for this research.

Dataset type

Health and disease

Keywords

Provenance

Purpose of dataset collection

Study

Source of data extraction

EPR

Image contrast

Not stated

Biological sample availability

None/not available

Structural Metadata

Details

Publishing frequency

Static

Version

1.0.0

Modified

13/10/2025

Distribution release date

30/09/2025

Citation Requirements

This publication uses data from the PATHWAY, an ethically approved Research Data Hub (NRES Reference 22/EE/0161)

Coverage

Start date

01/01/2019

End date

30/06/2025

Time lag

Variable

Geographic coverage

West Midlands

Follow-up

Other

Accessibility

Language

en

Alignment with standardised data models

LOCAL

Controlled vocabulary

ICD10, OPCS4

Format

CSV

Data Access Request

Dataset pipeline status

Not available

Access rights

Information Governance and Ethics - West Midlands Secure Data Environment (https://westmidlandssde.nhs.uk/information-governance-and-ethics)

Time to dataset access

Variable

Access request cost

Please email wmsde@uhb.nhs.uk

Access method category

TRE/SDE

Access service description

Data Request Process - West Midlands Secure Data Environment (https://westmidlandssde.nhs.uk/research/data-request)

Jurisdiction

GB

Data use limitation

Research-specific restrictions

Data use requirements

Project-specific restrictions

Data Controller

University Hospitals Birmingham NHS Foundation Trust

Data Processor

University Hospitals Birmingham NHS Foundation Trust

Dataset Types: Health and disease

Collection Sources: