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Assess determinants and understand strategies which may delay/halt aortic stenosis progression

Population Size

Not reported
Population Size statistic card

Years

2007 - 2020

Years statistic card

Associated BioSamples

None/not available

Associated BioSamples statistic card

Geographic coverage

West Midlands

Geographic coverage statistic card

Lead time

Variable

Lead time statistic card

Summary

A study to assess the determinants of aortic stenosis progression and to understand strategies which may delay/halt disease progression.

A dataset curated to determine which comorbidities and risk factors contribute to the progression of Aortic Stenosis and to develop a risk stratification tool to identify 'rapid progressors' who will benefit from targeted interventions (eg: Lp(a) lowering therapies) to reduce the need for aortic valve replacement.

Documentation

Aortic Stenosis is a condition which affects a valve in the heart by causing it to become stiff and narrowed, it develops over a number of years and affects mainly only older adults. The narrowing is caused by calcium build up on the valve making it stiff and difficult to open. The rate at which the valve narrows varies between people and is affected by the presence of other conditions and a protein in the blood called lipoprotein a. Currently the only treatment is valve replacement. However, for a score/tool to be developed which can categorise people according to their risk of rapidly progressing from mild to moderate to severe disease. Knowing who the rapid progressing are will allow for risk factor management and using a drug which lowers Lp(a) to slow disease progression avoiding the need for valve replacement.

Dataset type

Health and disease

Keywords

Provenance

Purpose of dataset collection

Study

Source of data extraction

EPR

Image contrast

Not stated

Biological sample availability

None/not available

Structural Metadata

Details

Publishing frequency

Static

Version

1.0.0

Modified

13/10/2025

Distribution release date

02/07/2025

Citation Requirements

This publication uses data from the PATHWAY, an ethically approved Research Data Hub (NRES Reference 22/EE/0161)

Coverage

Start date

01/01/2007

End date

01/01/2020

Time lag

Variable

Geographic coverage

West Midlands

Accessibility

Language

en

Alignment with standardised data models

LOCAL

Controlled vocabulary

ICD10, SNOMED CT, OPCS4

Format

CSV

Data Access Request

Dataset pipeline status

Not available

Access rights

Information Governance and Ethics - West Midlands Secure Data Environment (https://westmidlandssde.nhs.uk/information-governance-and-ethics)

Time to dataset access

Variable

Access request cost

Please email wmsde@uhb.nhs.uk

Access method category

TRE/SDE

Access service description

Data Request Process - West Midlands Secure Data Environment (https://westmidlandssde.nhs.uk/research/data-request)

Jurisdiction

GB

Data use limitation

Research-specific restrictions

Data use requirements

Ethics approval required,Project-specific restrictions

Data Controller

University Hospitals Birmingham NHS Foundation Trust

Data Processor

University Hospitals Birmingham NHS Foundation Trust

Dataset Types: Health and disease

Collection Sources: