A dataset of 552 patients who have been cared for on ICU.

Natriuretic peptides are special proteins produced by the heart, with the two key types being BNP and NT-proBNP. NT-proBNP is particularly useful in managing heart failure and assessing the risk of heart problems. This marker is not just for heart failure studies have suggested that NT-proBNP levels during the acute phase of sepsis may be a useful indicator of higher risk of long-term impairments in physical function and muscle strength in sepsis survivors.

This dataset includes detailed demographic information, comorbidities and admission reasons and journeys for patients who have required an intensive care admission. The data includes serial physiological and blood test measurements reflecting the severity of the patient’s condition, imaging and other investigative results, treatments, and outcomes. This data is invaluable in identifying the clinical utility of NT-proBNP as a potential prognostic marker for future complications and mortality.

PIONEER geography: The West Midlands (WM) has a population of 6.2 million & includes a diverse ethnic & socio-economic mix. EHR: UHB is one of the largest NHS Trusts in England, providing direct acute services & specialist care across four hospital sites, with 2.2 million patient episodes per year, 2750 beds & an expanded 250 ITU bed capacity during COVID. UHB runs a fully electronic healthcare record (EHR) (PICS Birmingham Systems), a shared primary & secondary care record (Your Care Connected) & a patient portal “My Health.”

Scope: Patients without chronic heart failure or acute heart failure diagnoses admitted to ICU with sepsis, acute respiratory failure (specifically ARDS) or polytrauma without severe head injury with at least one measurement of NT-proBNP at any time from 3-months pre-ICU admission to 6 months post-ICU discharge

Longitudinal & individually linked, so that the preceding & subsequent health journey can be mapped & healthcare utilisation prior to & after admission understood. The dataset includes highly granular patient demographics & co-morbidities taken from ICD-10 & SNOMED-CT codes. Serial, structured data pertaining to acute care process (timings, hospital mortality, Length of stays, readmissions), Intensive care details, primary diagnosis, SOFA score & APACHE II scores, NT-proBNP results & outcomes.

Available supplementary data: Matched controls ambulance, OMOP data, synthetic data.

Available supplementary support: PIONEER can also offer analytics, Model build, validation & refinement A.I. Data partner support for ETL (extract, transform & load) process, Clinical expertise, Patient & end-user access, Purchaser access, Regulatory requirements, Data-driven trials, “fast screen” services.

This research is supported by the National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre (BRC), specifically the Infections and Acute Care theme.