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INTERVAL

Population Size

Not reported
Population Size statistic card

Years

2012

Years statistic card

Associated BioSamples

DNA

Plasma

...see more

Associated BioSamples statistic card

Geographic coverage

United Kingdom

England

Geographic coverage statistic card

Lead time

2-6 months

Lead time statistic card

Summary

The INTERVAL bioresource comprises 50,000 English blood donors, on whom deep molecular phenotypes (e.g. genomics, proteomics, metabolomics, lipidomics) have been generated.

Documentation

In over 100 years of blood donation practice, INTERVAL is the first randomised controlled trial to assess the impact of varying the frequency of blood donation on donor health and the blood supply. It provided policy-makers with evidence that collecting blood more frequently than current intervals can be implemented over two years without impacting on donor health, allowing better management of the supply to the NHS of units of blood with in-demand blood groups. INTERVAL was designed to deliver a multi-purpose strategy: an initial purpose related to blood donation research aiming to improve NHS Blood and Transplant’s core services and a longer-term purpose related to the creation of a comprehensive resource that will enable detailed studies of health-related questions.

Approximately 50,000 generally healthy blood donors were recruited between June 2012 and June 2014 from 25 NHS Blood Donation centres across England. Approximately equal numbers of men and women; aged from 18-80; ~93% white ancestry. All participants completed brief online questionnaires at baseline and gave blood samples for research purposes. Participants were randomised to giving blood every 8/10/12 weeks (for men) and 12/14/16 weeks (for women) over a 2-year period. ~30,000 participants returned after 2 years and completed a brief online questionnaire and gave further blood samples for research purposes.

The baseline questionnaire includes brief lifestyle information (smoking, alcohol consumption, etc), iron-related questions (e.g., red meat consumption), self-reported height and weight, etc. The SF-36 questionnaire was completed online at baseline and 2-years, with a 6-monthly SF-12 questionnaire between baseline and 2-years.

All participants have had the Affymetrix Axiom UK Biobank genotyping array assayed and then imputed to 1000G+UK10K combined reference panel (80M variants in total). 4,000 participants have 50X whole-exome sequencing and 12,000 participants have 15X whole-genome sequencing. Whole-blood RNA sequencing has commenced in ~5,000 participants.

The dataset also contains data on clinical chemistry biomarkers, blood cell traits, >200 lipoproteins, metabolomics (Metabolon HD4), lipidomics, and proteomics (SomaLogic, Olink), either cohort-wide or is large sub-sets of the cohort.

Dataset type

Health and disease

Dataset sub-type

Not applicable

Keywords

Provenance

Purpose of dataset collection

Trial

Source of data extraction

Electronic survey

Collection source setting

Other

Image contrast

Not stated

Biological sample availability

DNA,Plasma,Serum,Whole blood

Details

Publishing frequency

Other

Version

1.0.0

Modified

08/10/2024

Citation Requirements

INTERVAL must be acknowledged in all publications using these data. Further details will be issued through the Data Access Committee.

Coverage

Start date

06/01/2012

Time lag

Not applicable

Geographic coverage

United Kingdom, England

Minimum age range

18

Maximum age range

80

Follow-up

Other

Accessibility

Language

en

Data Access Request

Dataset pipeline status

Not available

Time to dataset access

2-6 months

Access request cost

Cost recovery.

Access method category

TRE/SDE

Data use limitation

General research use

Data use requirements

Not for profit use,Return to database or resource,User-specific restriction

Data Controller

The University of Cambridge

Data Processor

The University of Cambridge

Dataset Types: Health and disease


Collection Sources: Other

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