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Observational Cohort Trial OCTAVE (OCTV)

Population Size

5,000

People

Years

2023

Associated BioSamples

None/not available

Geographic coverage

United Kingdom

Lead time

2-6 months

Summary

OCTAVE is a multi-disease, observational, cohort trial that will seek to understand the immune response to SARS-CoV-2 vaccinations in patients with certain immunosuppressed conditions.

Documentation

OCTAVE is a multi-disease, observational, cohort trial that will seek to understand the immune response to SARS-CoV-2 vaccinations in patients with certain immunosuppressed conditions.

Cohorts will include patients with chronic renal conditions, chronic liver conditions, inflammatory bowel disease, cancer (both solid and haematological malignancies), immune-mediated rheumatic/inflammatory conditions and haematopoietic stem cell transplant (HSCT) and chimeric antigen receptor (CAR) T recipients. OCTAVE is a collaborative research project involving academic partners from the Universities of Glasgow, Birmingham, Oxford, Imperial College London and the IMPACT network. The project is funded by the Medical Research Council, and badged as an Urgent Public Health trial supported by the NIHR Clinical Research Network.

Dataset type
Health and disease
Dataset sub-type
Not applicable
Dataset population size
5000
Associated media
https://www.youtube.com/watch?v=ZK9-Jw3uVkw, https://www.hdruk.ac.uk/news/covid-19-vaccine-data-listed-and-available-to-request-through-hdr-innovation-gateway/?utm_source=hive&utm_medium=email, https://saildatabank.com/about-us/, https://www.ukri.org/news/octave-study-shows-real-world-vaccine-response-in-at-risk-patients/

Keywords

Covid, COVID-19, NCS, National Core Study, core, Health & Wellbeing, OCTV

Observations

Observed Node
Disambiguating Description
Measured Value
Measured Property
Observation Date

Persons

Patients with immunocompromised or immunosuppressed conditions.

5000

Count

28 Sep 2021

Provenance

Source of data extraction
Other
Collection source setting
Other, Secondary care - In-patients
Patient pathway description
Covid-19, Cohorts will include patients with chronic renal conditions, chronic liver conditions, inflammatory bowel disease, cancer (both solid and haematological malignancies), immune-mediated rheumatic/inflammatory conditions and haematopoietic stem cell transplant (HSCT) and chimeric antigen receptor (CAR) T recipients.
Image contrast
Not stated
Biological sample availability
None/not available

Structural Metadata

Details

Publishing frequency
Daily
Version
1.0.0
Modified

08/10/2024

Citation Requirements
Digital Health and Care Wales (DHCW)

Coverage

Start date

01/01/2023

Time lag
Less than 1 week
Geographic coverage
United Kingdom
Maximum age range
120
Follow-up
Other

Accessibility

Language
en
Controlled vocabulary
LOCAL
Format
SQL database table

Data Access Request

Dataset pipeline status
Available
Access rights
https://saildatabank.com/data/apply-to-work-with-the-data/
Time to dataset access
2-6 months
Access request cost
Data provision is free from SAIL. Overall project costing depends on the number of people that require access to the SAIL Gateway, the activities that SAIL needs to complete (e.g. loading non-standard datasets), data refreshes, analytical work required, disclosure control process, and special case technological requirements.
Access service description
The SAIL Databank is powered by the UK Secure e-Research Platform (UKSeRP). Following approval through safeguard processes, access to project-specific data within the secure environment is permitted using two-factor authentication.
Jurisdiction
GB-GBN
Data use limitation
Research-specific restrictions
Data use requirements
Project-specific restrictions,User-specific restriction
Data Controller
SAIL Databank
Data Processor
SAIL Databank

Dataset Types: Health and disease

Collection Sources: Other, Secondary care - In-patients