The Human Developmental Biology Resource (HDBR) is an ongoing collection of human embryonic and fatal material ranging from 3 to 20 weeks of development. Material is available to researchers internationally following registration with the tissue bank. Jointly funded by the MRC and Wellcome Trust, the biobank has been operating since 1999 and is based at two centres: Institute of Genetic Medicine '“ Newcastle University and the Institute of Child Health '“ University College London. Tissues can be dissected to meet specific research needs and samples supplied fixed or frozen for histology or nucleic acid extraction, or the tissue can be collected into culture media to be used to establish cell lines. Material pre-sectioned to microscope slides is available for immunohistochemistry (IHC) or tissue in situ hybridisation studies (TISH) and stage, tissue specific RNA/DNA/cDNA can be requested. Our In House Gene Expression Service will perform IHC or TISH experiments on behalf of registered users and provide them with high quality annotated images of results ready for publication.