The NIHR Nottingham Digestive Diseases Biomedical Research Unit (NDDBRU) has become the central hub to the gastroenterology and hepatology research within the partnership of University of Nottingham and Nottingham University Trust, bringing together 67 principal investigators bridging basic scientific and clinical fields. Among this large group, we have expertise in a wide range of areas, techniques and methodologies although we focus on early translational studies including pre-clinical and phase I/II studies. We host large deeply phenotyped cohort of patients, linked databases and biological samples. Our academic partnership extends to industry links and we do have experience in developing and evaluating, drugs, devices and health care interventions. NIHR NDDBRU has a mission to take the most promising basic biomedical research breakthroughs and translate them into patient benefit. We focus on developing novel tests, techniques as well as new treatments. We perform experimental medicine investigations into mechanisms underlying disease processes using biological samples from people; we evaluate the efficacy of interventions in volunteers and patients. Our research focus is on 'The infections, inflammation and consequences in the GI tract and liver'.