The British Regional Heart Study (BRHS) is a long-term cohort investigating the causes of cardiovascular disease (CVD) in men and seeking to understand the effect of co-morbidities on CVD and ageing. The BRHS provides a geographically and socially representative cohort for the prospective investigation of CVD in British men spanning over four decades. Established in 1978-80, with 7735 male participants, the BRHS study has benefited from four repeated assessments of the men at ages in middle (40-59 years) and later life (60-79, 72-91 and 79-98 years). Participants have been followed up at four life stages for a wide range of health outcomes, including all-cause mortality and CVD morbidity, physical disability and frailty using GP records and participant questionnaires. This unique ageing cohort with extensive phenotyping, genotyping and detailed follow-up will contribute and allow us to study healthy cardiovascular ageing including prevention of CVD, heart failure, stroke, diabetes and related disabilities (frailty, dementia) in older age and to add to our understanding of the biological ageing process on CVD risk.

The survey data are accessible to bona fide researchers by applying direct to the study - https://www.ucl.ac.uk/epidemiology-health-care/research/primary-care-and-population-health/research/ageing/british-regional-heart-study-brhs/brhs-2

For further information on study description and data dictionaries please see the study webpages - https://www.ucl.ac.uk/epidemiology-health-care/research/primary-care-and-population-health/research/brhs